aspirin and taurocholic acid-induced gastric mucosal haemorrhage in rats

The eflect of orally administered prostaglandin 15(R)15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage has been studied in rats. The incidence of haemorrhage induced by aspirin (26-7 mM), 64 mg/kg, together with taurocholic acid (2.5 mM), was significantly reduced from 53l6% to 19l5% by the addition of the prostaglandin (9-9 ,uM), P < 0 01. The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 ,tM), P < 0-002. These results indicate the possible use of synthetic prostaglandins in the prevention of aspirininduced gastric pathology.